Yes, you can safely take paracetamol on an empty stomach. Unlike some other painkillers such as ibuprofen or aspirin, paracetamol does not irritate the stomach lining and is considered gentle on the digestive system[1][3][7].
The NHS confirms that taking paracetamol on an empty stomach is safe, and you do not need to eat beforehand. In fact, taking paracetamol with food could actually slow down its absorption and potentially make it less effective at relieving pain. Fasted stomach conditions allow paracetamol to reach peak plasma concentration more quickly, enhancing its action[1][2].
Pharmacokinetic studies show that while food slows the rate of absorption, the total amount of paracetamol absorbed remains the same. Peak levels in the blood occur sooner—about 20 minutes—when fasting, compared to 90 minutes when fed. High carbohydrate meals especially decrease peak plasma concentration[2].
For people with sensitive stomachs or a history of gastrointestinal problems, paracetamol is generally favored over NSAIDs, which are known to cause ulcers and stomach irritation. Paracetamol does not have the same ulcerogenic risk, making it a suitable choice for most adults needing pain relief, even if they have not eaten[3][5].
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